# limmunologylab.com


## Pages

- [Publications](https://limmunologylab.com/publications/): Publications Tumor-infiltrating Tim-3+ T cells proliferate avidly except when PD-1 is co-expressed: Evidence for intracellular cross talk Oncoimmunology 5:e1200778, 2016. Li J, Shayan G, Avery L, Jie HB, Gildener-Leapman N, Schmitt N, Lu BF, Kane LP, Ferris RL. Cetuximab ameliorates suppressive phenotypes of myeloid antigen presenting cells in head and neck cancer patients J Immunother Cancer 3:54, 2015. Li J, Srivastava RM, Ettyreddy A, Ferris RL.  PD-1/SHP-2 inhibits Tc1/Th1 phenotypic responses and the activation of T cells in the tumor microenvironment Cancer Research 75:508-518, 2015. Li J, Jie HB, Lei Y, Gildener-Leapman N, Trivedi S, Green T, Kane LP, Ferris […]
- [Main](https://limmunologylab.com/): Welcome to Li LAB Team Publications News 1. Regulation of Tumor Immunity by Regulatory CD8+ T cells Previously, we have demonstrated the important role of KIR+CD8+ regulatory T cells in maintenance of peripheral tolerance by suppressing autoreactive T cells. Since a large fraction of tumor antigens is derived from the self, we are curious whether the regulatory functions of KIR+CD8+ T cells extend to anti-tumor immunity. We will leverage cutting-edge technologies, mouse cancer models and patient-derived specimens to understand the role of KIR+/Ly49+CD8+ Tregs in regulating anti-tumor immunity and how their differentiation or functions are regulated by the tumor microenvironment. […]


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